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Stereoselective Synthesis of 4,5‐Dihydroisoxazole Derivatives from 1,1‐Dicyanocyclopropanes and Hydroxylamine Hydrochloride
Author(s) -
Zhang Yue,
Xin Junhu,
Wang Cunde
Publication year - 2021
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.202100032
Subject(s) - chemistry , hydroxylamine hydrochloride , hydroxylamine , stereoselectivity , hydrochloride , ethanol , cascade , combinatorial chemistry , organic chemistry , catalysis , chromatography
An efficient approach was developed for the synthesis of 4,5‐dihydroisoxazole derivatives from substituted 1,1‐dicyano‐cyclopropanes and hydroxylamine hydrochloride in ethanol through FeCl 3 ‐catalyzed cascade addition reactions. This procedure gives a useful method to afford stereoselectively poly‐substituted 4,5‐dihydroisoxazoles in good yields.
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