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A Close‐to‐Aromatize Approach for the Late‐Stage Functionalization through Ring Closing Metathesis
Author(s) -
Lozhkin Boris,
Ward Thomas R.
Publication year - 2021
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.202100024
Subject(s) - chemistry , ring closing metathesis , surface modification , metathesis , salt metathesis reaction , closing (real estate) , combinatorial chemistry , ring (chemistry) , substrate (aquarium) , organic chemistry , stereochemistry , oceanography , political science , law , polymerization , geology , polymer
An efficient approach for the synthesis of monosubstituted aromatic compounds relying on a ring‐closing metathesis followed by spontaneous 1,2‐elimination is presented. The efficiency for late‐stage functionalization is highlighted in various solvents (up to 920 TON). This approach is compatible with strained cycles and other multiple bonds in the substrate.