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Synthesis of Enantiopure Benzo Fused Cyclic Sulfoximines Through Stereoselective [3+2] Cycloaddition between N ‐ tert ‐Butanesulfinyl [(2‐Pyridyl)sulfonyl]‐difluoromethyl Ketimines and Arynes
Author(s) -
Rong Jian,
Ni Chuanfa,
Gu Yucheng,
Hu Jinbo
Publication year - 2021
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.202100019
Subject(s) - enantiopure drug , chemistry , cycloaddition , stereoselectivity , sulfonyl , aryne , stereochemistry , medicinal chemistry , enantioselective synthesis , organic chemistry , catalysis , alkyl
The previously developed stereoselective [3+2] cycloaddition between N ‐ tert ‐butanesulfinyl ketimines and arynes has been extended to the synthesis of enantiopure [(2‐pyridyl)sulfonyl]difluoromethylated cyclic sulfoximines. The use of 2‐PySO 2 CF 2 as the facilitating group offers new opportunities for the elaboration of the [3+2] cycloaddition products by virtue of the diverse relativity of 2‐pyridyl sulfones.