Synthesis of Enantiopure Benzo Fused Cyclic Sulfoximines Through Stereoselective [3+2] Cycloaddition between  N ‐ tert ‐Butanesulfinyl [(2‐Pyridyl)sulfonyl]‐difluoromethyl Ketimines and Arynes | Zendy

Rong Jian | Zendy; Ni Chuanfa | Zendy; Gu Yucheng | Zendy; Hu Jinbo | Zendy

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Synthesis of Enantiopure Benzo Fused Cyclic Sulfoximines Through Stereoselective [3+2] Cycloaddition between N ‐ tert ‐Butanesulfinyl [(2‐Pyridyl)sulfonyl]‐difluoromethyl Ketimines and Arynes

Author(s) -

Rong Jian,

Ni Chuanfa,

Gu Yucheng,

Hu Jinbo

Publication year - 2021

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.202100019

Subject(s) - enantiopure drug , chemistry , cycloaddition , stereoselectivity , sulfonyl , aryne , stereochemistry , medicinal chemistry , enantioselective synthesis , organic chemistry , catalysis , alkyl

The previously developed stereoselective [3+2] cycloaddition between N ‐ tert ‐butanesulfinyl ketimines and arynes has been extended to the synthesis of enantiopure [(2‐pyridyl)sulfonyl]difluoromethylated cyclic sulfoximines. The use of 2‐PySO 2 CF 2 as the facilitating group offers new opportunities for the elaboration of the [3+2] cycloaddition products by virtue of the diverse relativity of 2‐pyridyl sulfones.

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