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Transition Metal‐Free Alkyne‐Aldehyde Reductive C−C Coupling trough Cascade Borylation/Olefin Isomerization
Author(s) -
Khan Imran,
Luo Zhibin,
Xu Yin,
Xie Jimin,
Zhu Weihua,
Liu Bin
Publication year - 2020
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.202000028
Subject(s) - chemistry , alkyne , isomerization , aldehyde , cascade , propargyl , borylation , olefin fiber , transition metal , organic chemistry , combinatorial chemistry , photochemistry , catalysis , alkyl , chromatography , aryl
A direct approach to γ ‐keto esters through cascade alkyne‐aldehyde reductive C−C coupling of propargyl esters and aromatic aldehydes under transition‐metal‐free (TM‐free) fashion was developed. Compared with multistep processes, this procedure provides a fast path using commercially available materials and could be handled conveniently to produce various γ ‐keto esters in moderate yields.