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Anhydrous Conditions Enable the Catalyst‐Free Carboxylation of Aromatic Alkynes with CO 2 under Mild Conditions
Author(s) -
Toniolo Davide,
Bobbink Felix D.,
Dyson Paul J.,
Mazzanti Marinella
Publication year - 2020
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201900258
Subject(s) - carboxylation , chemistry , anhydrous , catalysis , yield (engineering) , organic chemistry , combinatorial chemistry , materials science , metallurgy
Abstract The direct carboxylation of aromatic alkynes with CO 2 , a cheap and widely available C1 source, is the most attractive method for the synthesis of carboxylic acids. Here we show that direct carboxylation of terminal alkynes can be simply performed in near‐quantitative yield in four hours with anhydrous Cs 2 CO 3 under mild conditions without need of a metal catalyst.