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Diastereoselective Hydroxyethylation of β ‐Hydroxyketones: A Reformatsky Cyclization‐Lactone Reduction Cascade Mediated by SmI 2 −H 2 O
Author(s) -
GarduñoCastro Monserrat H.,
Procter David J.
Publication year - 2019
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201900227
Subject(s) - chemistry , reformatsky reaction , lactone , stereochemistry , reduction (mathematics) , cascade , medicinal chemistry , geometry , mathematics , chromatography
The hydroxyethylation of β ‐hydroxyketones allows diastereoselective access to important 1,3,5‐triols. The approach exploits a SmI 2 −H 2 O‐mediated Reformatsky cyclization‐lactone reduction cascade.