Premium
Asymmetric Synthesis of 2,3‐Disubstituted Cyclic Ketones by Enantioselective Conjugate Radical Additions
Author(s) -
Nad Sukanya,
Sibi Mukund P.
Publication year - 2019
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201900223
Subject(s) - chemistry , enantioselective synthesis , conjugate , yield (engineering) , chiral lewis acid , lewis acids and bases , organic chemistry , stereochemistry , catalysis , mathematical analysis , materials science , mathematics , metallurgy
Abstract Enantioselective conjugate radical addition to 2‐acyloxymethyl cycloalkenones proceeds in high yield with outstanding diastereoselectivity and excellent enantioselectivity using chiral salen Lewis acids. The process provides access to 2,3‐disubstituted cycloalkanones, a structural motif present in natural products.