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Asymmetric Synthesis of 2,3‐Disubstituted Cyclic Ketones by Enantioselective Conjugate Radical Additions
Author(s) -
Nad Sukanya,
Sibi Mukund P.
Publication year - 2019
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201900223
Subject(s) - chemistry , enantioselective synthesis , conjugate , yield (engineering) , chiral lewis acid , lewis acids and bases , organic chemistry , stereochemistry , catalysis , mathematical analysis , materials science , mathematics , metallurgy
Enantioselective conjugate radical addition to 2‐acyloxymethyl cycloalkenones proceeds in high yield with outstanding diastereoselectivity and excellent enantioselectivity using chiral salen Lewis acids. The process provides access to 2,3‐disubstituted cycloalkanones, a structural motif present in natural products.
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