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Enhancement of Acid‐Catalyzed Esterification by the Addition of Base
Author(s) -
Kihara Nobuhiro,
Matsumoto Yasuhiro,
Tsukamoto Shunsuke
Publication year - 2019
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201900154
Subject(s) - chemistry , imidazole , benzoic acid , catalysis , base (topology) , chloroform , organic chemistry , acid–base reaction , medicinal chemistry , mathematical analysis , mathematics
General acid‐catalyzed reaction can be enhanced by the addition of base. Self‐catalyzed esterification of benzoic acid and octan‐1‐ol was enhanced by the addition of certain base such as imidazole. The rate of the esterification was accelerated as the concentration of imidazole increased. Trans‐esterification of 4‐nitrophenyl acetate was promoted in chloroform by the mixture of benzoic acid and imidazole, but not by benzoic acid or imidazole alone.