Total Synthesis of Fontanesine B and Its Isomer: Their Antiproliferative Activity against Human Colorectal Cancer Cells | Zendy

Abe Takumi | Zendy; Itoh Tomoki | Zendy; Terasaki Masaru | Zendy

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Total Synthesis of Fontanesine B and Its Isomer: Their Antiproliferative Activity against Human Colorectal Cancer Cells

Author(s) -

Abe Takumi,

Itoh Tomoki,

Terasaki Masaru

Publication year - 2019

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.201900116

Subject(s) - chemistry , stereochemistry , indole test , natural product , colorectal cancer , total synthesis , in vitro , pyran , alkene , ring (chemistry) , cancer , biochemistry , organic chemistry , catalysis , medicine

A concise synthesis of pyrano[3,2‐ e ]indole alkaloid fontanesine B by a Fischer indolization is described. This key Fischer indolization starts with the pyran‐ring and alkene intact, facilitating potential synthetic applications. Furthermore, fontanesine B and its isomer were evaluated for in vitro antiproliferative activity against human colorectal cancer cells. The isomer of fontanesine B showed higher antiproliferative activity than the natural product, fontanesine B ( 2 ).

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