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Evaluation of the Potential of Cobalamin Derivatives Bearing Ru(II) Polypyridyl Complexes as Photosensitizers for Photodynamic Therapy
Author(s) -
Jakubaszek Marta,
Rossier Jeremie,
Karges Johannes,
Delasoie Joachim,
Goud Bruno,
Gasser Gilles,
Zobi Fabio
Publication year - 2019
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201900104
Subject(s) - photodynamic therapy , ruthenium , cobalamin , chemistry , combinatorial chemistry , cancer therapy , selectivity , cancer , photochemistry , cancer research , biochemistry , medicine , vitamin b12 , catalysis , organic chemistry
The current photosensitizers (PSs) for photodynamic therapy (PDT) lack selectivity for cancer cells. To tackle this drawback, in view of selective cancer delivery, we envisioned conjugating two ruthenium polypyridyl complexes to vitamin B 12 (Cobalamin, Cbl) to take advantage of the solubility and active uptake of the latter. Ultimately, our results showed that the transcobalamin pathway is unlikely involved for the delivery of these ruthenium‐based PDT PSs, emphasizing the difficulty in successfully delivering metal complexes to cancer cells.