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Hydrogenation towards Synthetic Sandalwood Odorants in Fragrance Industry
Author(s) -
Dupau Philippe
Publication year - 2018
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201800144
Subject(s) - chemistry , sandalwood , hydride , catalysis , homogeneous , organic chemistry , hydrosilylation , reagent , green chemistry , hydrogen , transfer hydrogenation , combinatorial chemistry , reaction mechanism , ruthenium , physics , thermodynamics , archaeology , history
The use of metal hydrides as historical reagents for selective carbonyl group reduction is often still a really highly convenient solution for laboratory‐scale transformations due to the lack of requirement for specific equipment. Nevertheless, based on safety, environmental, but also economical industrial constraints, metal hydride reductions were replaced by hydrosilylation, hydrogen transfer, and mostly hydrogenation reactions. Among many other advantages, the use of hydrogen as a reducing agent indeed represents the most sustainable solution for implementation of such chemical transformation on industrial scale. Whereas heterogeneous catalysts have been initially sparsely employed, the most recent developments towards the synthesis of highly active and efficient homogeneous catalysts have become an indisputable solution for selective hydrogenation of both ketones and aldehydes in sandalwood odorant production according to green chemistry principles.