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A Gold‐ and Brønsted Acid Catalytic Interplay Towards the Synthesis of Highly Substituted Tetrahydrocarbazoles
Author(s) -
Garayalde David,
Rusconi Giulia,
Nevado Cristina
Publication year - 2017
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201600333
Subject(s) - chemistry , brønsted–lowry acid–base theory , catalysis , lewis acids and bases , combinatorial chemistry , organic chemistry
The reaction of indoles and stabilized cyclopropyl alkynes under gold‐ and/or gold & Brønsted acid‐catalysis provided access to highly substituted tetrahydrocarbazoles. A mechanistic study revealed the complex mechanism underlying these processes and the opportunistic cooperation of Lewis and Brønsted acid‐catalysts towards the formation of complex molecular scaffolds.