Fast Efficient and General PASE Approach to Medicinally Relevant 4 H ,5 H ‐Pyrano‐[4,3‐ b ]pyran‐5‐one and 4,6‐Dihydro‐5 H ‐pyrano‐[3,2‐ c ]pyridine‐5‐one Scaffolds | Zendy

Elinson Michail N. | Zendy; Ryzhkov Fedor V. | Zendy; Nasybullin Ruslan F. | Zendy; Vereshchagin Anatoly N. | Zendy; Egorov Mikhail P. | Zendy

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Fast Efficient and General PASE Approach to Medicinally Relevant 4 H ,5 H ‐Pyrano‐[4,3‐ b ]pyran‐5‐one and 4,6‐Dihydro‐5 H ‐pyrano‐[3,2‐ c ]pyridine‐5‐one Scaffolds

Author(s) -

Elinson Michail N.,

Ryzhkov Fedor V.,

Nasybullin Ruslan F.,

Vereshchagin Anatoly N.,

Egorov Mikhail P.

Publication year - 2016

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.201600150

Subject(s) - chemistry , pyran , ammonium acetate , pyridine , solvent , ammonium , combinatorial chemistry , stereochemistry , organic chemistry , medicinal chemistry , high performance liquid chromatography

The general ‘on‐solvent’ PASE approach was found to be medicinally relevant for 4 H ,5 H ‐pyrano[4,3‐ b ]pyran‐5‐one and 4,6‐dihydro‐5 H ‐pyrano[3,2‐ c ]pyridine‐5‐one scaffolds. Ammonium acetate‐catalyzed multicomponent reaction of aldehydes and two different C–H acids in the presence of small amounts of EtOH results in fast (3 – 15 min) and efficient formation of scaffolds, promising for many diverse oriented medical applications.

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