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Fast Efficient and General PASE Approach to Medicinally Relevant 4 H ,5 H ‐Pyrano‐[4,3‐ b ]pyran‐5‐one and 4,6‐Dihydro‐5 H ‐pyrano‐[3,2‐ c ]pyridine‐5‐one Scaffolds
Author(s) -
Elinson Michail N.,
Ryzhkov Fedor V.,
Nasybullin Ruslan F.,
Vereshchagin Anatoly N.,
Egorov Mikhail P.
Publication year - 2016
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201600150
Subject(s) - chemistry , pyran , ammonium acetate , pyridine , solvent , ammonium , combinatorial chemistry , stereochemistry , organic chemistry , medicinal chemistry , high performance liquid chromatography
The general ‘on‐solvent’ PASE approach was found to be medicinally relevant for 4 H ,5 H ‐pyrano[4,3‐ b ]pyran‐5‐one and 4,6‐dihydro‐5 H ‐pyrano[3,2‐ c ]pyridine‐5‐one scaffolds. Ammonium acetate‐catalyzed multicomponent reaction of aldehydes and two different C–H acids in the presence of small amounts of EtOH results in fast (3 – 15 min) and efficient formation of scaffolds, promising for many diverse oriented medical applications.