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Aloeverasides A and B: Two Bioactive C ‐Glucosyl Chromones from Aloe vera Resin
Author(s) -
Rehman Najeeb Ur,
Hussain Hidayat,
Khiat Mohammed,
AlRiyami Samia Ahmed,
Csuk René,
Khan Husain Yar,
Abbas Ghulam,
AlThani Ghanim Salim,
Green Ivan R.,
AlHarrasi Ahmed
Publication year - 2016
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201600126
Subject(s) - chemistry , antioxidant , aloe vera , enzyme , heteronuclear single quantum coherence spectroscopy , stereochemistry , urease , dept , two dimensional nuclear magnetic resonance spectroscopy , carbon 13 nmr , organic chemistry , traditional medicine , medicine
Two new C ‐glucosyl chromones named aloeverasides A ( 1 ) and B ( 2 ) were isolated from the resin of Aloe vera (L.) B urm.f . The structures of the two new natural products were elucidated based on 1D‐ ( 1 H‐ and 13 C‐NMR) and 2D‐NMR (COSY, HSQC, and HMBC) spectroscopic techniques and mass spectrometry (ESI‐MS). Aloeverasides A ( 1 ) and B ( 2 ) were evaluated for their anticancer activity, and both induced a 76.4 and 70.5% growth inhibition of the breast cancer cell line (MDA‐MB‐231) at a concentration of 100 μ m . Both compounds were also evaluated for their 1,1‐diphenyl‐2‐picryl‐hydrazyl antioxidant, urease enzyme, and α ‐glucosidase enzyme inhibition activities. Aloeverasides A ( 1 ) and B ( 2 ) displayed good urease enzyme inhibition activities (62 and 55%, resp.), as well as antioxidant activity in which aloeveraside A ( 1 ) had a value of 60% inhibition, while aloeveraside B ( 2 ) demonstrated a more potent antioxidant activity with 80% inhibition.