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Lyciumaside and Lyciumate: A New Diacylglycoside and Sesquiterpene Lactone from Lycium shawii
Author(s) -
Rehman Najeeb Ur,
Hussain Hidayat,
AlRiyami Samia Ahmed,
Csuk René,
Khiat Mohammed,
Abbas Ghulam,
AlRawahi Ahmed,
Green Ivan R.,
Ahmed Ishtiaq,
AlHarrasi Ahmed
Publication year - 2016
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201600066
Subject(s) - chemistry , sesquiterpene , sesquiterpene lactone , heteronuclear single quantum coherence spectroscopy , stereochemistry , two dimensional nuclear magnetic resonance spectroscopy , lycium , lactone , carbon 13 nmr , dept , medicine , alternative medicine , pathology
One new diacylglycoside named lyciumaside ( 1 ) and a new sesquiterpene lactone named lyciumate ( 2 ) were isolated from Lycium shawii Roem . & Schult . The structures of the two new compounds were elucidated based on 1D‐ ( 1 H‐ and 13 C‐ NMR and NOE ) and 2D‐ NMR ( COSY , HSQC , and HMBC ) spectroscopic techniques, and mass spectrometry ( ESI‐MS ). Preliminary evaluations demonstrated lyciumaside ( 1 ) possesses strong antioxidant activity with an IC 50 = 30 μg/ml (80% inhibition) while it was inactive in α ‐glucosidase and urease enzymes assays.