Thiosemicarbazone Scaffold as a Multidentate Ligand for Transition‐Metal Ions: Synthesis, Characterization,  In Vitro  Antimicrobial, Anthelmintic,  DNA  Cleavage, and Cytotoxic Studies | Zendy

Maddireddy Manjunatha | Zendy; Kulkarni Ajaykumar D. | Zendy; Bagihalli Gangadhar B. | Zendy; Malladi Shridhar | Zendy

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Thiosemicarbazone Scaffold as a Multidentate Ligand for Transition‐Metal Ions: Synthesis, Characterization, In Vitro Antimicrobial, Anthelmintic, DNA Cleavage, and Cytotoxic Studies

Author(s) -

Maddireddy Manjunatha,

Kulkarni Ajaykumar D.,

Bagihalli Gangadhar B.,

Malladi Shridhar

Publication year - 2016

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.201600045

Subject(s) - chemistry , agarose gel electrophoresis , isatin , denticity , schiff base , aspergillus niger , octahedral molecular geometry , monobasic acid , nuclear chemistry , metal , metal ions in aqueous solution , ligand (biochemistry) , stereochemistry , dna , polymer chemistry , organic chemistry , biochemistry , receptor

New series of Schiff bases derived from o ‐substituted thiosemicarbazides and 8‐formyl‐7‐hydroxy‐4‐methylcoumarin have been synthesized and their coordination tendency toward Co(II), Ni(II), and Cu(II) metal ions is studied. Analytical, spectral ( IR , UV ‐Vis, ESR , and FAB ‐mass), magnetic, and thermal studies suggests octahedral geometry of the type ML 2 for all the Co(II), Ni(II), and Cu(II) complexes. The complexes are soluble in DMF / DMSO and are non‐electrolytes. The Schiff bases and their metal complexes have been screened for antibacterial ( Escherichia coli , Staphylococcus aureus , Salmonella typhi , and Pseudomonas aeruginosa ) and antifungal activities ( Aspergillus flavus , Aspergillus niger , and Cladosporium ) by minimum inhibitory concentration method. DNA cleavage is studied by agarose gel electrophoresis method. Metal ( II ) complexes show good anthelmintic activity when compared to Schiff bases.

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