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Thiosemicarbazone Scaffold as a Multidentate Ligand for Transition‐Metal Ions: Synthesis, Characterization, In Vitro Antimicrobial, Anthelmintic, DNA Cleavage, and Cytotoxic Studies
Author(s) -
Maddireddy Manjunatha,
Kulkarni Ajaykumar D.,
Bagihalli Gangadhar B.,
Malladi Shridhar
Publication year - 2016
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201600045
Subject(s) - chemistry , agarose gel electrophoresis , isatin , denticity , schiff base , aspergillus niger , octahedral molecular geometry , monobasic acid , nuclear chemistry , metal , metal ions in aqueous solution , ligand (biochemistry) , stereochemistry , dna , polymer chemistry , organic chemistry , biochemistry , receptor
New series of Schiff bases derived from o ‐substituted thiosemicarbazides and 8‐formyl‐7‐hydroxy‐4‐methylcoumarin have been synthesized and their coordination tendency toward Co(II), Ni(II), and Cu(II) metal ions is studied. Analytical, spectral ( IR , UV ‐Vis, ESR , and FAB ‐mass), magnetic, and thermal studies suggests octahedral geometry of the type ML 2 for all the Co(II), Ni(II), and Cu(II) complexes. The complexes are soluble in DMF / DMSO and are non‐electrolytes. The Schiff bases and their metal complexes have been screened for antibacterial ( Escherichia coli , Staphylococcus aureus , Salmonella typhi , and Pseudomonas aeruginosa ) and antifungal activities ( Aspergillus flavus , Aspergillus niger , and Cladosporium ) by minimum inhibitory concentration method. DNA cleavage is studied by agarose gel electrophoresis method. Metal ( II ) complexes show good anthelmintic activity when compared to Schiff bases.