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Aurovertin‐Type Polyketides from Calcarisporium arbuscula with Potent Cytotoxic Activities against Triple‐Negative Breast Cancer
Author(s) -
Zhao Hong,
Wu Rui,
Ma LieFeng,
Wo LiKe,
Hu YuanYuan,
Chen Chao,
Zhan ZhaJun
Publication year - 2016
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201600026
Subject(s) - chemistry , cytotoxic t cell , polyene , triple negative breast cancer , stereochemistry , cancer cell lines , fungus , cancer , breast cancer , cancer cell , biochemistry , botany , in vitro , genetics , biology
Two new polyene polyketides, namely aurovertins T and U ( 1 and 2 ), were isolated from Calcarisporium arbuscula , together with aurovertins B ( 3 ), D and E ( 4 and 5 ), and M ( 6 ). The structures were elucidated by extensive spectroscopic methods (especially 2D‐ NMR techniques). The cytotoxic activities of all isolates against human triple‐negative breast cancer cell line ( MDA ‐ MB ‐231) were evaluated. As a result, compounds 3 , 4 , and 6 exhibited more potent cytotoxic activities against MDA ‐ MB ‐231 cell line than the positive control taxol. Also, discussion about the relationships between structure and activity of these aurovertins was presented.