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Three New Pregnane Alkaloids from Pachysandra terminalis
Author(s) -
Sun Yun,
Chen JinXiong,
Chen JianChao,
Li ZhongRong,
Zhou Lin,
Li Yan,
Qiu MingHua
Publication year - 2016
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201600016
Subject(s) - chemistry , pregnane , isopropyl , cytotoxicity , stereochemistry , organic chemistry , in vitro , biochemistry
Three new pregnane alkaloids, pachystermine C ( 1 ), pachysanamine A ( 2 ), and pachysanamine B ( 3 ), together with four known ones, pachystermine B ( 4 ), pachysamine A ( 5 ), (20 S )‐20‐(dimethylamino)‐16 α ‐hydroxy‐3 β ‐(3′ α ‐isopropyl)lactam‐5 α ‐pregnan‐4‐one ( 6 ), and E ‐salignone ( 7 ), were isolated from Pachysandra terminalis . The chemical structures of the new alkaloids were elucidated by spectroscopic methods. All the compounds were evaluated for their inhibitory activities against HL‐60, SMMC‐7721, A‐549, MCF‐7, and SW480 cell lines, some of the compounds showed stronger cytotoxicity for the test cell lines, especially compounds 2 , 3 , and 7 .