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An Efficient Stereoselective Synthesis of Key Fragments of Elaiophylin
Author(s) -
Padmaja Pannala,
Reddy Pedavenkatagari Narayana,
Yadav Jhillu Singh
Publication year - 2016
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201600006
Subject(s) - chemistry , stereoselectivity , pyridinium chlorochromate , metathesis , oxidative cleavage , kinetic resolution , pyridinium , prins reaction , organic chemistry , salt metathesis reaction , stereochemistry , combinatorial chemistry , enantioselective synthesis , catalysis , polymerization , polymer
The stereoselective synthesis of key fragments 3 and 7 of elaiophylin has been accomplished from readily available epichlorohydrin as the starting material. The key reactions involved are Jacobsen 's kinetic resolution, Prins cyclization, pyridinium chlorochromate‐mediated oxidative cleavage, Grignard reaction, and cross‐metathesis reaction.