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Two New Nimbolinin‐Type Limonoids from the Fruits of Melia toosendan
Author(s) -
Zhang Qiong,
Zhang YongGang,
Li QingShan,
Min ZhiDa
Publication year - 2016
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201500516
Subject(s) - chemistry , limonoid , meliaceae , stereochemistry , traditional medicine , type (biology) , terpene , cytotoxicity , in vitro , biology , biochemistry , medicine , ecology
Two new nimbolinin‐type limonoids, 12‐ethoxynimbolinins E and F ( 1 and 2 , resp.), together with seven known analogues, 1 α ‐benzoyloxy‐3 α ‐acetoxyl‐7 α ‐hydroxy‐12 β ‐ethoxynimbolinin ( 3 ), nimbolinin B ( 4 ), meliatoosenin L ( 5 ), 14,15‐deoxy‐11‐oxohavanensin 3,12‐diacetate ( 6 ), 12 α ‐hydroxymeliatoosenin ( 7 ), toosendansin A ( 8 ), and toosendansin C ( 9 ), were isolated from the fruits of Melia toosendan . The structures of these compounds were elucidated by spectroscopic analysis. All the compounds were evaluated for their cytotoxicity against five tumor cell lines.