CuBr/Et 3 N‐Promoted Reactions of 2‐Aminobenzamides and Isothiocyanates: Efficient Synthesis of Novel Quinazolin‐4(3 H )‐ones | Zendy

Mahdavi Mohammad | Zendy; Asadi Mehdi | Zendy; Khoshbakht Mahsa | Zendy; Saeedi Mina | Zendy; Bayat Mohammad | Zendy; Foroumadi Alireza | Zendy; Shafiee Abbas | Zendy

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CuBr/Et 3 N‐Promoted Reactions of 2‐Aminobenzamides and Isothiocyanates: Efficient Synthesis of Novel Quinazolin‐4(3 H )‐ones

Author(s) -

Mahdavi Mohammad,

Asadi Mehdi,

Khoshbakht Mahsa,

Saeedi Mina,

Bayat Mohammad,

Foroumadi Alireza,

Shafiee Abbas

Publication year - 2016

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.201500273

Subject(s) - chemistry , yield (engineering) , aryl , organic chemistry , combinatorial chemistry , medicinal chemistry , alkyl , materials science , metallurgy

A series of novel quinazolin‐4(3 H )‐one derivatives were efficiently synthesized starting from isatoic anhydride. First, reaction of isatoic anhydride and amines in H 2 O at room temperature afforded 2‐aminobenzamides. Then, CuBr/Et 3 N promoted reaction of 2‐aminobenzamides and different aryl isothiocyanates in DMF at 80° afforded the title compounds in good yield.

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