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CuBr/Et 3 N‐Promoted Reactions of 2‐Aminobenzamides and Isothiocyanates: Efficient Synthesis of Novel Quinazolin‐4(3 H )‐ones
Author(s) -
Mahdavi Mohammad,
Asadi Mehdi,
Khoshbakht Mahsa,
Saeedi Mina,
Bayat Mohammad,
Foroumadi Alireza,
Shafiee Abbas
Publication year - 2016
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201500273
Subject(s) - chemistry , yield (engineering) , aryl , organic chemistry , combinatorial chemistry , medicinal chemistry , alkyl , materials science , metallurgy
A series of novel quinazolin‐4(3 H )‐one derivatives were efficiently synthesized starting from isatoic anhydride. First, reaction of isatoic anhydride and amines in H 2 O at room temperature afforded 2‐aminobenzamides. Then, CuBr/Et 3 N promoted reaction of 2‐aminobenzamides and different aryl isothiocyanates in DMF at 80° afforded the title compounds in good yield.