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Two New Flavonoids from Derris eriocarpa How
Author(s) -
Lou HuaYong,
Wu HongGuo,
Tan YongHua,
Lan JunJie,
Ma XiaoPan,
Liang GuangYi,
Yi Ping,
Pan WeiDong
Publication year - 2016
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201500247
Subject(s) - chemistry , stereochemistry , herb , two dimensional nuclear magnetic resonance spectroscopy , medicinal herbs , traditional medicine , medicine
Two new flavonoids, 1 and 2 , together with two known flavonoids, tephrosin ( 3 ) and 12a‐hydroxy‐ α ‐toxicarol ( 4 ), were isolated from the whole herb of Derris eriocarpa How . The structures and absolute configurations of the new compounds were elucidated on the basis of their MS , NMR , and ECD data. The structures of the known compounds were established by extensive spectroscopic ( MS , 1D‐ and 2D‐ NMR ) analyses and comparison with the literature data. All compounds were isolated from D . eriocarpa for the first time. Compound 3 showed modest inhibitory activities against the growth of human cancer cells HEL and A549 with the IC 50 values of 15.03 ± 0.62 and 13.27 ± 0.39 μ m , respectively.
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