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Four New Pregnane Steroids from Aglaia abbreviata and Their Cytotoxic Activities
Author(s) -
Zhang Feng,
Zhu Yu,
Li Qin,
Cen Juan
Publication year - 2016
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201500228
Subject(s) - chemistry , pregnane , cytotoxic t cell , k562 cells , human breast , steroid , cell culture , cytotoxicity , leukemia , stereochemistry , cancer cell , pharmacology , cancer , cell , biochemistry , medicine , in vitro , biology , genetics , hormone
Four new pregnane steroids, aglaiasterols A–D ( 1 – 4 ), have been isolated from the EtOH extract of stems of Aglaia abbreviata. They were identified as (3 α ,5 α ,17 Z )‐3‐hydroxypregn‐17‐en‐16‐one ( 1 ), (3 β ,5 α ,17 E )‐3‐hydroxypregn‐17‐en‐16‐one ( 2 ), (3 β ,5 α ,17 Z )‐3‐hydroxypregn‐17‐en‐16‐one ( 3 ), and (3 α ,5 α ,20 S* )‐3‐hydroxy‐16‐oxopregnan‐20‐yl acetate ( 4 ) on the basis of spectroscopic methods, including 1D‐ and 2D‐NMR techniques. Compounds 1 – 4 were evaluated for their cytotoxic activities against K562 (human leukemia), MCF‐7 (human breast cancer), and KB (human oral epithelium cancer) cells, and drug‐resistant cells of K562/A02, MCF‐7/ADM, and KB/VCR. These isolates showed weak to moderate inhibitory effects on the growth of the tested cell lines.