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Stilbenoids and Phenols in Acanthopanax brachypus
Author(s) -
Hu HaoBin,
Liang HaiPeng,
Zheng XuDong,
Wu Yun,
Zhang XiaoWei
Publication year - 2015
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201500227
Subject(s) - chemistry , resveratrol , phenols , stereochemistry , cytotoxicity , polyphenol , spectral analysis , organic chemistry , antioxidant , biochemistry , spectroscopy , quantum mechanics , physics , in vitro
Three new stilbenoids, including α ‐(3′‐ O ‐ β ‐ D ‐glucopyranosyl‐5′‐methoxyphenyl)‐2‐methoxy‐3‐methylbenzofuran ( 1 ), 4‐methyl‐( E )‐resveratrol 3‐(2″‐ p ‐hydroxybenzoyl)‐ O ‐ β ‐ D ‐glucopyranoside ( 2 ), and 5‐ O ‐methyl‐( E )‐resveratrol 3‐(6″‐acetyl)‐ O ‐ β ‐ D ‐glucopyranoside ( 3 ), together with six known stilbenoids and phenols, acetovanillone 1‐(6′‐vanilloyl)‐ O ‐ β ‐ D ‐glucopyranoside, eugenyl‐ O ‐ β ‐ D ‐glucopyranoside, α ‐(3′‐hydroxy‐5′‐methoxy‐2′‐methylphenyl)‐2‐hydroxybenzofuran, α ‐(3′‐hydroxy‐5′‐methoxyphenyl)‐2‐hydroxybenzofuran, pinosilvin 3‐ O ‐ β ‐ D ‐glucopyranoside, and ( E )‐resveratrol 3‐(6″‐galloyl)‐ O ‐ β ‐ D ‐glucopyranoside were isolated from the EtOH extract of the stem bark of Acanthopanax brachypus. Their structures were determined by spectral analysis including extensive 2D‐NMR spectral analyses. Compounds 2 and 3 exhibited weak cytotoxicity against human tumor A549 cell line ( IC 50 values of 4.87 and 5.63 μ M , resp.).