Stilbenoids and Phenols in Acanthopanax brachypus

Three new stilbenoids, including α ‐(3′‐ O ‐ β ‐ D ‐glucopyranosyl‐5′‐methoxyphenyl)‐2‐methoxy‐3‐methylbenzofuran ( 1 ), 4‐methyl‐( E )‐resveratrol 3‐(2″‐ p ‐hydroxybenzoyl)‐ O ‐ β ‐ D ‐glucopyranoside ( 2 ), and 5‐ O ‐methyl‐( E )‐resveratrol 3‐(6″‐acetyl)‐ O ‐ β ‐ D ‐glucopyranoside ( 3 ), together with six known stilbenoids and phenols, acetovanillone 1‐(6′‐vanilloyl)‐ O ‐ β ‐ D ‐glucopyranoside, eugenyl‐ O ‐ β ‐ D ‐glucopyranoside, α ‐(3′‐hydroxy‐5′‐methoxy‐2′‐methylphenyl)‐2‐hydroxybenzofuran, α ‐(3′‐hydroxy‐5′‐methoxyphenyl)‐2‐hydroxybenzofuran, pinosilvin 3‐ O ‐ β ‐ D ‐glucopyranoside, and ( E )‐resveratrol 3‐(6″‐galloyl)‐ O ‐ β ‐ D ‐glucopyranoside were isolated from the EtOH extract of the stem bark of Acanthopanax brachypus. Their structures were determined by spectral analysis including extensive 2D‐NMR spectral analyses. Compounds 2 and 3 exhibited weak cytotoxicity against human tumor A549 cell line ( IC 50 values of 4.87 and 5.63 μ M , resp.).