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New ent ‐Pimarane Diterpenes from the Roots of Aralia dumetorum
Author(s) -
Yang ChunTao,
Hou ShuQun,
Tian Kai,
Hu QiuFen,
Huang XiangZhong,
Jiang ZhiYong
Publication year - 2016
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201500221
Subject(s) - chemistry , stereochemistry , diterpene
Four new ent ‐pimarane diterpenes were isolated from the EtOH extract of A ralia dumetorum , together with three known compounds involving ent ‐pimar‐8(14),15‐dien‐19‐oic acid ( 5 ), ent ‐pimar‐8(14),15‐dien‐19‐ol ( 6 ), and ent ‐kaur‐16‐en‐19‐oic acid ( 7 ). By detailed analyses of the MS , IR , and NMR data, the structures of four new diterpenes were characterized as (5 β ,9 β ,10 α ,13 α )‐pimara‐6,8(14),15‐trien‐18‐oic acid ( 1 ), (5 β ,7 β, 9 β ,10 α ,13 α )‐7‐methoxypimara‐8(14),15‐dien‐18‐oic acid ( 2 ), (5 β ,9 β ,10 α ,13 α ,14 β )‐14‐methoxypimara‐7,15‐dien‐18‐oic acid ( 3 ), and (5 β ,10 α ,13 α ,14 α )‐14‐hydroxypimara‐7,9(11),15‐trien‐18‐oic acid ( 4 ). The cytotoxic activities of compounds 1 – 7 were assayed in vitro through MTT method.