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Myrothecoside, a Novel Glycosylated Polyketide from the Terrestrial Fungus Myrothecium sp. GS ‐17
Author(s) -
Zhang Songya,
Zhu Jing,
Liu Tao,
Samra Suzan,
Pan Huaqi,
Bai Jiao,
Hua Huiming,
Bechthold Andreas
Publication year - 2016
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201500218
Subject(s) - chemistry , fusarium oxysporum , polyketide , two dimensional nuclear magnetic resonance spectroscopy , rhizoctonia solani , fungus , stereochemistry , glycoside , cytotoxicity , antifungal , fusarium solani , pathogenic fungus , microbiology and biotechnology , botany , biochemistry , biosynthesis , biology , enzyme , gene , in vitro
Based on the chemical analysis and targeted bioactivity screening, a new polyketide glycoside, myrothecoside, was isolated from a terrestrial halotolerant fungus, Myrothecium sp. GS ‐17. The structure of myrothecoside was elucidated on the basis of extensive spectroscopic analysis including 1D‐ and 2D‐ NMR ( 1 H, 1 H‐ COSY , HSQC , HMBC , and NOESY ) experiments, combined with mass spectroscopic data and physicochemical properties. This compound exhibited weak cytotoxicity against human leukemia ( HL ‐60) cancer cell with an IG 50 value of 63.61 μ m , and also antifungal activities against plant pathogenic fungi Rhizoctonia solani and Fusarium oxysporum using standard agar diffusion tests at 20 μg/disk.
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