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Vinmajorines C – E, Monoterpenoid Indole Alkaloids from Vinca major
Author(s) -
Zhang ZhiJun,
Du RuNan,
He Juan,
Wu XingDe,
Li Yan,
Li RongTao,
Zhao QinShi
Publication year - 2016
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201500211
Subject(s) - chemistry , vinca , stereochemistry , indole test , apocynaceae , cytotoxic t cell , monoterpene , organic chemistry , traditional medicine , biochemistry , in vitro , botany , medicine , biology
Three new monoterpenoid indole alkaloids, vinmajorines C–E ( 1 – 3 ), along with 18 known analogues ( 4 – 21 ), were isolated from the whole plants of Vinca major. The new structures were elucidated as (5 α ,15 β ,16 R ,17 α ,19 β ,20 α ,21 β )‐10,17‐dimethoxy‐21‐methyl‐18‐oxa‐5,16‐cycloyohimban‐19‐ol ( 1 ), (5 α ,15 β ,16 R ,17 α ,20 α ,21 β )‐10‐methoxy‐21‐methyl‐18‐oxa‐5,16‐cycloyohimban‐17‐ol ( 2 ), and (5 α ,15 β ,16 R ,17 α ,20 α ,21 β )‐10‐methoxy‐21‐methyl‐18‐oxa‐5,16‐cycloyohimban‐17‐yl acetate ( 3 ), respectively, by extensive NMR and MS analysis and comparison with known compounds. Compounds 1 – 3 were evaluated for their cytotoxic activities against five human cancer cell lines, compounds 1 and 3 showing moderate cytotoxic activities.