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Furanyl Alcohols as Alkylating Reagents in Friedel – Crafts Reaction of Arenes
Author(s) -
Iesce Maria Rosaria,
Sferruzza Rosalia,
Cermola Flavio,
DellaGreca Marina
Publication year - 2016
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201500196
Subject(s) - chemistry , friedel–crafts reaction , reagent , lignan , organic chemistry , reaction conditions , medicinal chemistry , catalysis
Furanyl alcohols react with arenes by a variant of the Friedel–Crafts reaction to give benzyl furans with fairly satisfying yields. The reaction is mediated by Tf 2 O and occurs with reduced times in the presence of Ph 3 PO. Some prepared compounds exhibit a lignan‐like backbone.