An Efficient Stereoselective Total Synthesis of Bioactive (3 R ,5 R )‐1‐(4‐Hydroxyphenyl)‐7‐phenylheptane‐3,5‐diol  via  Asymmetric Aldol Reaction | Zendy

Ramesh Perla | Zendy; Raju Atla | Zendy; Fadnavis Nitin W. | Zendy

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An Efficient Stereoselective Total Synthesis of Bioactive (3 R ,5 R )‐1‐(4‐Hydroxyphenyl)‐7‐phenylheptane‐3,5‐diol via Asymmetric Aldol Reaction

Author(s) -

Ramesh Perla,

Raju Atla,

Fadnavis Nitin W.

Publication year - 2016

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.201500189

Subject(s) - chemistry , stereoselectivity , aldol reaction , diol , yield (engineering) , total synthesis , cinnamaldehyde , stereochemistry , organic chemistry , catalysis , materials science , metallurgy

An efficient stereoselective total synthesis of (3 R ,5 R )‐1‐(4‐hydroxyphenyl)‐7‐phenylheptane‐3,5‐diol ( 1 ) is reported based on the Mukaiyama aldol reaction. The total synthesis of compound 1 was accomplished with 30% overall yield in simple eight steps from commercially available trans ‐cinnamaldehyde.

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