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An Efficient Stereoselective Total Synthesis of Bioactive (3 R ,5 R )‐1‐(4‐Hydroxyphenyl)‐7‐phenylheptane‐3,5‐diol via Asymmetric Aldol Reaction
Author(s) -
Ramesh Perla,
Raju Atla,
Fadnavis Nitin W.
Publication year - 2016
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201500189
Subject(s) - chemistry , stereoselectivity , aldol reaction , diol , yield (engineering) , total synthesis , cinnamaldehyde , stereochemistry , organic chemistry , catalysis , materials science , metallurgy
An efficient stereoselective total synthesis of (3 R ,5 R )‐1‐(4‐hydroxyphenyl)‐7‐phenylheptane‐3,5‐diol ( 1 ) is reported based on the Mukaiyama aldol reaction. The total synthesis of compound 1 was accomplished with 30% overall yield in simple eight steps from commercially available trans ‐cinnamaldehyde.