Trichodermates A–F, New Cytotoxic Trichothecenes from the Plant Pathogenic Fungus  Trichoderma  sp. | Zendy

Li Jiaying | Zendy; Ren Jinwei | Zendy; Bao Li | Zendy; Jin Tao | Zendy; Wang Wenzhao | Zendy; Pei Yunfei | Zendy; Liu Xingzhong | Zendy; Li Erwei | Zendy

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Trichodermates A–F, New Cytotoxic Trichothecenes from the Plant Pathogenic Fungus Trichoderma sp.

Author(s) -

Li Jiaying,

Ren Jinwei,

Bao Li,

Jin Tao,

Wang Wenzhao,

Pei Yunfei,

Liu Xingzhong,

Li Erwei

Publication year - 2016

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.201500182

Subject(s) - chemistry , trichothecene , fungus , absolute configuration , stereochemistry , cytotoxic t cell , circular dichroism , polyketide , fermentation , hydrolysis , mycotoxin , botany , organic chemistry , biochemistry , biosynthesis , in vitro , food science , enzyme , biology

Trichodermates A – F ( 1 – 6 , resp.), six new trichothecene polyunsaturated octadioic acid esters, and (−)‐harzianum B ( 7 ) were isolated from the fermentation extract of Trichoderma sp., a plant pathogenic fungus isolated from stem rot of an unidentified tree in Thailand. The structures of 1 – 7 were elucidated by NMR experiments. The absolute configuration at C(12) in 3 was assigned by in situ dimolybdenum circular dichroism method, whereas that in 7 was deduced after hydrolysis of 7 to 8 via modified Mosher 's method. Compounds 1 and 2 showed modest cytotoxic activities against the K562 (human myelogenous leukemia) cell line with IC 50 values of 12.12 and 13.08 μ M , respectively.

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