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Seven New Acyl Glycosides from Erycibe obtusifolia
Author(s) -
Feng ZiMing,
Liu ZhaoZhen,
Xu Kuo,
Yang YaNan,
Jiang JianShuang,
Zhang PeiCheng
Publication year - 2016
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201500143
Subject(s) - chemistry , coumarin , glycoside , stereochemistry , carcinoma , traditional medicine , medicine , organic chemistry
Seven new acyl glycosides, benzyl 5‐ O ‐vanilloyl ‐β ‐ d ‐apiofuranosyl‐(1→6)‐ β ‐ d ‐glucopyranoside ( 1 ), 4‐hydroxy‐3‐methoxyphenyl 5‐ O ‐syringoyl‐ β ‐ d ‐apiofuranosyl‐(1→6)‐ β ‐ d ‐glucopyranoside ( 2 ), isopentyl 5‐ O ‐syringoyl‐ β ‐ d ‐apiofuranosyl‐(1→6)‐ β ‐ d ‐glucopyranoside ( 3 ), 3,4,5‐trimethoxyphenyl 5‐ O ‐sinapoyl‐ β ‐ d ‐apiofuranosyl‐(1→6)‐ β ‐ d ‐glucopyranoside ( 4 ), 6‐methoxy‐7‐[(6‐ O ‐sinapoyl‐ β ‐ d ‐glucopyranosyl)oxy]coumarin ( 5 ), 6‐methoxy‐7‐[(2‐ O ‐sinapoyl‐ β ‐ d ‐glucopyranosyl)oxy]coumarin ( 6 ), and isopentyl β ‐ d ‐apiofuranosyl‐(1→6)‐[5‐ O ‐syringoyl‐ β ‐ d ‐apiofuranosyl‐(1→2)]‐ β ‐ d ‐glucopyranoside ( 7 ), were isolated from Chinese folk herb Erycibe obtusifolia . Their structures were elucidated on the basis of extensive spectroscopic analysis, including UV , IR , MS , and 1D‐ and 2D‐ NMR techniques. Further, these compounds were evaluated against HCT ‐8 (human colon carcinoma), Bel‐7402 (human liver carcinoma), BGC ‐823 (human stomach carcinoma), A549 (human lung carcinoma), and A2780 (human ovarian carcinoma) cell lines, however, none of them exhibited a significant bioactivity ( IC 50 > 10 μ m ).