Premium
Paeonenoides D and E: Two New Nortriterpenoids from Paeonia lactiflora and Their Inhibitory Activities on NO Production
Author(s) -
Fu Qiang,
Qiu Lu,
Yuan HaiMei,
Yu Tian,
Zou Liang
Publication year - 2016
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201500130
Subject(s) - chemistry , paeonia lactiflora , cytotoxic t cell , stereochemistry , inhibitory postsynaptic potential , triterpenoid , terpene , terpenoid , traditional medicine , biochemistry , in vitro , biology , endocrinology , medicine , alternative medicine , pathology
Two new nortriterpenoids, paeonenoides D and E ( 1 and 2 , resp.), together with seven known compounds, were isolated from the roots of Paeonia lactiflora. Their structures were elucidated on the basis of spectroscopic evidence. Compounds 1 – 7 were screened for inhibitory effects against NO production in LPS‐induced RAW246.7 macrophages and for cytotoxic activities against HL‐60, Hep‐G2, and SK‐OV‐3 cell lines. Compounds 1 – 3 and 5 – 7 exhibited inhibitory activities with IC 50 values in the range of 9.6–32.2 μ M . Triterpenoids with an epoxide ring and a free COOH function, 1 – 3 , showed effectively increased activities compared with other pentacyclic triterpenoids. Compounds 1 – 6 showed significant cytotoxic activities against the Hep‐G2 cell line and modest cytotoxic activities against HL‐60 and SK‐OV‐3 cell lines.