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In vitro Antioxidant Activity of Ubiquinone and Ubiquinol, Compared to Vitamin E
Author(s) -
Cervellati Rinaldo,
Greco Emanuela
Publication year - 2016
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201500124
Subject(s) - coenzyme q10 , ubiquinol , chemistry , antioxidant , free radical scavenger , scavenger , dpph , vitamin c , vitamin e , coenzyme q – cytochrome c reductase , biochemistry , vitamin , in vitro , oxidative stress , mitochondrion , cytochrome c
Abstract Coenzyme Q10 (CoQ10) is the prevalent ubiquinone in human organism, largely present in its reduced form, ubiquinol (QH 2 ), to which the antioxidant, free radical scavenger activity is ascribed by many authors. However, some studies indicate that also the oxidized form presents some effect in preventing the cellular oxidative stress. In this article four in vitro chemical test methods (TEAC, FRAP, DPPH, and BR) were used to assess the free radical scavenging power of CoQ10, QH 2 , and vitamin E. The results showed that CoQ10 is almost ineffective, while in three of the tests QH 2 presents a higher antioxidant activity than vitamin E. From these results, it can be concluded that the interconversion CoQ10⇌QH 2 leading to the prevalence of QH 2 in biological tissues is responsible for the antioxidant action of coenzyme Q10 in living organisms.