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Synthesis of Novel Isoindolo[2,1‐ a ]quinazolinedione Derivatives Containing a 1,2,3‐Triazole Ring System
Author(s) -
EsmaeiliMarandi Fatemeh,
Saeedi Mina,
Yavari Issa,
Mahdavi Mohammad,
Shafiee Abbas
Publication year - 2016
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201500122
Subject(s) - chemistry , ring (chemistry) , triazole , quinazoline , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry
A synthesis of isoindolo[2,1‐ a ]quinazolinedione derivatives, coupled with a 1,2,3‐triazole ring system, via the reaction of isatoic anhydride, HCCCH 2 NH 2 , and 2‐formylbenzoic acid is described, which led to the formation of the isoindolo[2,1‐ a ]quinazoline‐5,11‐dione scaffold having a CC bond that participated in a click reaction with various organic azides.