Premium
Pseudonocardides A – G, New γ ‐Butyrolactones from Marine‐derived Pseudonocardia sp. YIM M13669
Author(s) -
Zhang XiaoMei,
Zhang DaoFeng,
Li WenJun,
Lu ChunHua
Publication year - 2016
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201500109
Subject(s) - chemistry , stereochemistry , derivative (finance) , mycobacterium smegmatis , antibacterial activity , strain (injury) , two dimensional nuclear magnetic resonance spectroscopy , bacteria , mycobacterium tuberculosis , medicine , tuberculosis , pathology , biology , financial economics , economics , genetics
Seven new γ ‐butyrolactones, named pseudonocardides A – G ( 1 – 7 ), were isolated from the marine‐derived actinomycete strain Pseudonocardia sp. YIM M13669. Their structures were elucidated on the basis of spectroscopic data including 1D‐ and 2D‐ NMR , and HR ‐ ESI ‐ MS . The absolute configuration of 1 was determined by X‐ray crystallographic analysis of 1a (4‐bromobenzoate derivative of 1 ). The antibacterial activity against Mycobacterium smegmatis MC 2 155 and cytotoxicities of compounds 1 – 7 were evaluated in this study.