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Bioactive Trichothecenes Produced by the Myrothecium sp. QB‐1
Author(s) -
Ren Ren,
Chen ChaoJun,
Liu XianXian,
Ge HuiMing,
Tan RenXiang,
Jiao RuiHua
Publication year - 2015
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201500088
Subject(s) - chemistry , antifungal , strain (injury) , stereochemistry , two dimensional nuclear magnetic resonance spectroscopy , microbiology and biotechnology , medicine , biology
Three new simple trichothecenes, 15‐acetyltrichoverrol B ( 3 ), 13′‐acetyltrichoverrin B ( 5 ), and 6′‐dehydroxytrichoverrin B ( 6 ), along with five known trichothecenes trichodermadienediol B ( 1 ), trichoverrol B ( 2 ), trichoverrin B ( 4 ), and roridins A ( 7 ) and D ( 8 ), have been isolated from the liquid culture of Myrothecium roridum (strain no. QB‐1). The structures of the new compounds were established by comprehensive analysis of 1D‐ and 2D‐NMR data. All the compounds were evaluated for antifungal activity, only compounds 7 and 8 showed significant antifungal activity against the tested fungi ( MIC ranged from 10 to 5 μg/ml).