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Concise Synthesis of 2‐Arylpropanoic Acids and Study of Unprecedented Reduction of 3‐Hydroxy‐2‐arylpropenoic Acid Ethyl Ester to 2‐Arylpropenoic Acid Ethyl Ester by BH 3 ⋅THF
Author(s) -
Shahid Islam M.,
Ahmad Syarhabil,
Attu Mary Rose,
Foerstering F. Holger,
Mahmun Hossain M.
Publication year - 2015
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201500062
Subject(s) - chemistry , ethyl ester , benzaldehyde , organic chemistry , combinatorial chemistry , catalysis
We have developed a concise method of synthesizing racemic arylpropanoic acids, which have been widely used as nonsteroidal anti‐inflammatory drugs (NSAIDs). The synthesis involves only four steps from commercially available benzaldehyde. The synthesis incorporates an unprecedented reduction reaction, conversion of 3‐hydroxy‐2‐arylpropenoic acid ethyl ester to 2‐arylpropenoic acid ethyl ester by BH 3 ⋅THF. The reduction reaction has been investigated and optimized.