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One‐Pot Synthesis of 3‐Alkoxy‐2,3‐dihydro‐1 H ‐isoindol‐1‐ones by the Reactions of 2‐(Azidomethyl)benzoates with NaH
Author(s) -
Kobayashi Kazuhiro,
Chikazawa Yuuki,
Ezaki Kosuke
Publication year - 2015
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201500051
Subject(s) - benzoates , chemistry , alkoxy group , medicinal chemistry , halide , alkyl , organic chemistry
A new and facile method for the general preparation of 3‐alkoxy‐2,3‐dihydro‐1 H ‐isoindol‐1‐ones has been developed. Thus, the reaction of 2‐(azidomethyl)benzoates with NaH affords, after workup with H 2 O, 3‐alkoxy‐2,3‐dihydro‐1 H ‐isoindol‐1‐ones 2 . 2‐Substituted 3‐alkoxy‐2,3‐dihydro‐1 H ‐isoindol‐1‐ones 4 can be obtained by adding alkyl halides prior to workup with H 2 O.
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