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Three New Lignan Derivatives from Lindera glauca ( Siebold et Zucc .) Blume
Author(s) -
Suh Won Se,
Kim Ki Hyun,
Kim Ho Kyung,
Choi Sang Un,
Lee Kang Ro
Publication year - 2015
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201500002
Subject(s) - lignan , chemistry , glycoside , sulforhodamine b , stereochemistry , cytotoxicity , circular dichroism , lauraceae , acid hydrolysis , two dimensional nuclear magnetic resonance spectroscopy , in vitro , biochemistry , hydrolysis , botany , biology
Two new aryl‐tetralin lignan glycosides, linderanosides A and B ( 1 and 2 , resp.), and a new dihydrobenzofuran neolignan glycoside, linderanoside C ( 3 ), together with five known lignan derivatives ( 4 – 8 ) were isolated from the trunk of Lindera glauca. The structures of these new compounds were determined through spectroscopic analyses, including extensive 2D‐NMR data and acid hydrolysis. The absolute configurations of the compounds were clarified by circular dichroism (CD) spectroscopic studies. Compounds 1 – 8 were evaluated for their cytotoxicity against A549 (non‐small cell lung adenocarcinoma), SK‐OV‐3 (ovarian cancer cells), A498 (human kidney epithelial cells), and HCT‐15 (colon cancer cells) human tumor cell lines using sulforhodamine B assays in vitro.