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Two New Flavanols from Glycosmis pentaphylla and Their Cytotoxic Activities
Author(s) -
Wang Jiangfeng,
Zhao Bing,
Zhang Feng,
Zhang Qiongyu
Publication year - 2016
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201400362
Subject(s) - chemistry , cytotoxic t cell , stereochemistry , biochemistry , in vitro
Two new flavanols, (8 S ,9 R )‐9,10‐dihydro‐5,9‐dihydroxy‐8‐(3,4,5‐trimethoxyphenyl)‐2 H ,8 H ‐benzo[1,2‐ b: 3,4‐ b′ ]dipyran‐2‐one ( 1 ) and (2 S ,3 R )‐3,4‐dihydro‐3,5‐dihydroxy‐2‐(3,4,5‐trimethoxyphenyl)‐2 H ,8 H ‐benzo[1,2‐ b: 3,4‐ b′ ]dipyran‐8‐one ( 2 ), were isolated from the stems of Glycosmis pentaphylla. The structures of these compounds were determined by extensive spectroscopic (UV, IR, HR‐ESI‐MS, 1D‐ and 2D‐NMR) analyses. The cytotoxic activities of these compounds were evaluated using the MTT method. The results showed that compounds 1 and 2 exhibited considerable cytotoxic activities against HL‐60 and A549 cell lines.