Premium
New Casbane Diterpenoids from the Hainan Soft Coral Sinularia Species
Author(s) -
Yang Bin,
Huang Jingxia,
Lin Xiuping,
Liao Shengrong,
Zhou Xuefeng,
Liu Juan,
Wang Junfeng,
Wang Lishu,
Liu Yonghong
Publication year - 2015
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201400341
Subject(s) - chemistry , coral , hela , hl60 , cytotoxicity , stereochemistry , cancer cell lines , two dimensional nuclear magnetic resonance spectroscopy , cell culture , cancer cell , biochemistry , cell , cancer , in vitro , ecology , medicine , biology , genetics
Six new casbane diterpenoids, sinularcasbanes G–L ( 1 – 6 , resp.) were isolated from the soft coral Sinularia sp. Their structures were established by extensive spectroscopic analyses, especially 2D‐NMR and HR‐ESI‐MS. The configuration was confirmed by CD analyses and by comparison with data reported in the literature. The compounds were evaluated for cytotoxicity against ten human cancer cell lines (H1975, U937, K562, BGC823, MOLT‐4, MCF‐7, A549, HeLa, HL60, and Huh‐7) and showed no activity.