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Facile Synthesis of 5‐Hexyl‐4‐methyl‐ γ ‐butyrolactone via Nef Reaction as a Key Step
Author(s) -
Li Zhi,
Wang Changwei,
Feng Pengju
Publication year - 2015
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201400327
Subject(s) - chemistry , reagent , alkyl , combinatorial chemistry , key (lock) , organic chemistry , biology , ecology
A racemic cis / trans mixture of 5‐hexyl‐4‐methyl‐ γ ‐butyrolactone was easily synthesized from 1‐iodoheptane in four steps with inexpensive and readily available reagents. Our new synthesis method can be potentially employed for mass production of the 4‐methyl‐5‐hexyl‐ γ ‐butyrolactone as well as other poly‐alkyl substituted γ ‐butyrolactones.
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