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Paecilomycines A and B, Novel Diterpenoids, Isolated from Insect‐Pathogenic Fungi Paecilomyces sp. ACCC 37762
Author(s) -
Zhou Kun,
Zhao XiaoLing,
Han LiPing,
Cao MengMeng,
Chen Chuan,
Shi BaoZhong,
Luo DuQiang
Publication year - 2015
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201400272
Subject(s) - chemistry , paecilomyces , labdane , stereochemistry , insect , terpenoid , strain (injury) , diterpene , ring (chemistry) , botany , organic chemistry , biology , anatomy
Two new diterpenoids, named paecilomycine A ( 1 ) and paecilomycine B ( 2 ), including a novel skeleton with a five‐membered lactone ring, together with three known labdane diterpenoids, rel ‐(1 R ,3 S ,4a S ,5 R ,8a S )‐5‐[(3 E )‐4‐carboxy‐3‐methylbut‐3‐en‐1‐yl]decahydro‐3‐hydroxy‐1,4a‐dimethyl‐6‐methylidenenaphthalene‐1‐carboxylic acid ( 3 ), botryosphaerin E ( 4 ), and agathic acid ( 5 ), were isolated from solid culture of the insect pathogenic fungi strain Paecilomyces sp. The structures of all compounds were established on the basis of comprehensive spectroscopic studies. The relative configurations of 1 and 2 were determined by single‐crystal X‐ray diffraction analyses.