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Synthesis of 6‐Aminoindolo[2,1‐ a ]isoquinoline‐5‐carbonitriles by the Cu‐Catalyzed Reaction of 2‐(2‐Bromophenyl)‐1 H ‐indoles with CH 2 (CN) 2
Author(s) -
Kobayashi Kazuhiro,
Ezaki Kosuke,
Hanioka Daisuke,
Nozawa Ippei
Publication year - 2015
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201400271
Subject(s) - isoquinoline , chemistry , catalysis , indole test , medicinal chemistry , organic chemistry
A series of 6‐aminoindolo[2,1‐ a ]isoquinoline‐5‐carbonitriles 4 have been prepared by treatment of 2‐(2‐bromophenyl)‐1 H ‐indoles 1 , available from 1‐(2‐bromophenyl)ethanones or 1‐(2‐bromophenyl)propan‐1‐ones by using Fischer indole synthesis, with propanedinitrile in the presence of a catalytic amount of CuBr and an excess of K 2 CO 3 in DMSO at 100°.
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