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Copper‐Catalyzed Synthesis of Pentasubstituted Pyridines from N ‐Sulfonyl Ketenimines, 1,1,3,3‐Tetramethylguanidine, and Acetylene Dicarboxylates
Author(s) -
Yavari Issa,
Sheikhi Azam,
Nematpour Manijeh,
Taheri Zohreh
Publication year - 2015
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201400255
Subject(s) - chemistry , sulfonyl , acetylene , regioselectivity , catalysis , adduct , dimethyl acetylenedicarboxylate , copper , medicinal chemistry , organic chemistry , cycloaddition , alkyl
Regioselective synthesis of pentasubstituted pyridines has been developed in moderate‐to‐good yields by the reaction of sulfonyl azides, alkynes, and a dialkyl acetylenedicarboxylatetetramethylguanidine adduct catalyzed by CuI in MeCN at room temperature.