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Steroidal Alkaloids from Veratrum maackii Regel with Genotoxicity on Brain‐Cell DNA in Mice
Author(s) -
Cong Yue,
Zhu HuaLan,
Zhang QingChun,
Li Lin,
Li HaiYan,
Wang XianYou,
Guo JingGong
Publication year - 2015
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201400238
Subject(s) - chemistry , genotoxicity , comet assay , dna , gel electrophoresis , dna damage , microbiology and biotechnology , biochemistry , organic chemistry , toxicity , biology
Two new steroidal alkaloids, 23‐methoxycyclopamine 3‐ O ‐ β‐ D ‐glucopyranoside ( 1 ) and isoecliptalbine ( 2 ), were isolated from the root and rhizoma of Veratrum maackii Regel , together with five known compounds, i.e. , verussurine ( 3 ), verabenzoamine ( 4 ), verazine ( 5 ), isoverazine ( 6 ), and verazinine ( 7 ). Their structures were established by extensive analysis of spectroscopic data, as well as by comparison with literature data. Compounds 1 – 7 could cause DNA damage in the cerebellum and cerebral cortex of mice in a dose‐dependent manner by using single‐cell gel electrophoresis (comet assay).