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Stereoselective Total Synthesis of Crassalactone A, a Natural Cytotoxic Styryl Lactone
Author(s) -
Raghavendar Reddy Parigi,
Das Biswanath
Publication year - 2015
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201400237
Subject(s) - chemistry , stereoselectivity , aldehyde , lactone , total synthesis , reagent , stereochemistry , grignard reagent , tartrate , enantioselective synthesis , organic chemistry , catalysis
A stereoselective total synthesis of a naturally occurring cytotoxic styryl lactone, crassalactone A ( 1 ), has been accomplished. The synthesis involves (−)‐diisopropyl D ‐tartrate as the starting material, and the stereoselective additions of Grignard reagent and MeNO 2 to two chiral aldehyde intermediates as the key steps.