Premium
New Triterpenoid Glycosides from the Roots of Camellia oleifera Abel
Author(s) -
Li Xia,
Zhao Jianping,
Li Xiaoran,
Liu Yanli,
Xu Qiongming,
Khan Ikhlas A.,
Yang Shilin
Publication year - 2015
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201400208
Subject(s) - chemistry , triterpenoid , aglycone , oleanane , glycoside , stereochemistry , bromide , camellia oleifera , cytotoxicity , two dimensional nuclear magnetic resonance spectroscopy , in vitro , organic chemistry , triterpene , biochemistry , medicine , alternative medicine , pathology
Five new triterpenoid saponins, oleiferosides I–M ( 1 – 5 , resp.) were isolated from the roots of Camellia oleifera Abel . Their structures were elucidated by a combination of 1D‐ and 2D‐NMR spectroscopy, mass spectrometry, and chemical methods. All the compounds were identified as oleanane‐type saponins with sugar moieties linked to C(3) of the aglycone. In addition, cytotoxic activities of these saponins were evaluated against four human tumor cell lines (A549, B16, BEL‐7402, and MCF‐7) by using the 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) in vitro assay. All of the compounds showed significant cytotoxic activities against the tested cell lines.