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Stereoselective Total Synthesis of Decytospolides A and B Starting from D ‐Mannitol
Author(s) -
Srilatha Malampati,
Das Biswanath
Publication year - 2015
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201400200
Subject(s) - chemistry , stereoselectivity , tetrahydropyran , intramolecular force , amide , stereochemistry , total synthesis , mannitol , d mannitol , ring (chemistry) , molecule , organic chemistry , catalysis
Abstract The stereoselective total synthesis of decytospolides A and B, two naturally occurring pyran derivatives, has been achieved using D ‐mannitol as the starting material. The intramolecular oxa‐ Michael reaction has been employed to construct the tetrahydropyran ring of the molecules and Weinreb amide formation to generate their side chain with a keto function.