First Stereoselective Synthesis of the Cytotoxic Polyketide (4 R )‐1‐(3,5‐Dihydroxyphenyl)‐4‐hydroxypentan‐2‐one | Zendy

Rajendra Prasad Kothakonda | Zendy; Purushotham Reddy Sudina | Zendy; Suresh Babu Katragadda | Zendy; Madhusudana Rao Janaswamy | Zendy

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First Stereoselective Synthesis of the Cytotoxic Polyketide (4 R )‐1‐(3,5‐Dihydroxyphenyl)‐4‐hydroxypentan‐2‐one

Author(s) -

Rajendra Prasad Kothakonda,

Purushotham Reddy Sudina,

Suresh Babu Katragadda,

Madhusudana Rao Janaswamy

Publication year - 2015

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.201400158

Subject(s) - chemistry , stereoselectivity , polyketide , stereochemistry , kinetic resolution , cytotoxic t cell , grignard reaction , hydrolysis , alcohol , combinatorial chemistry , enantioselective synthesis , organic chemistry , enzyme , biosynthesis , in vitro , catalysis , biochemistry , reagent

The first stereoselective synthesis of the cytotoxic polyketide (4 R )‐1‐(3,5‐dihydroxyphenyl)‐4‐hydroxypentan‐2‐one ( 1 ) was achieved from readily available propylene oxide and 3,5‐dimethoxybenzyl alcohol. The synthesis involves Jacobsen 's hydrolytic kinetic resolution (HKR) and Grignard reaction as key steps.

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